Contaminants of emerging concern (CECs) are chemicals whose presence in the environment, and potential effects on human health and biodiversity, have only recently begun to be investigated. CECs include a wide range of chemicals used in different applications, e.g. pharmaceuticals, personal-care products, biocides, etc. Within CONTRAST, we aim to develop a monitoring framework based on an Integrated Assessment Framework (IAF), combining chemical measurements together with biological effects endpoints to detect the presence and degree of effect of CECs in the marine environment, using areas in European seas as case studies. The knowledge gained will form the basis for guidance documents and policy briefs on the best practices for performing an IAF on CECs in the marine environment. Furthermore, the interactions of climate change drivers on CECs will be evaluated including effects on CECs distribution, circulation, fate, bioavailability, and toxicity to marine life.